Mechanisms Involved in Diabetes-Associated Platelet Hyperactivation (by MedTech ExPress Continuing Education)

1 P.A.C.E. contact hour(s)

(based on 1 customer ratings)

MedTech ExPress Continuing Education, LLC

Platelets play a key role in thrombosis and hemostasis. However, recent evidence clearly demonstrates that the functional role of platelets extends into many other processes in the body. In this course, a detailed physiological overview of platelet activation is first presented by the author. The roles of factors such as insulin resistance, hyperglycemia, and dyslipidemia on platelet function are then explained. Finally, the student is introduced to the intracellular mechanisms underlying platelet hyper-reactivity in diabetes, as well as the impact diabetes has on the responsiveness to anti-platelet therapy.

See more courses in: Hematology; Coagulation

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification) (MedTech ExPress): 1 hour(s)
Course number 301-802-17, approved through 2/28/2019
Course number 20-591434, approved through 2/28/2019

Objectives

  • outline the normal characteristics and physiological roles of platelets, and describe how these are affected by diabetes.
  • recount the molecular processes involved in the various stages of normal platelet activation, function, and degradation.
  • identify the parameters used by clinical laboratories to assess and quantify platelets.
  • describe the normal role of insulin in platelet activation, and recall how this role is altered diabetic patients.
  • recognize altered physiological processes seen of diabetic patients, and the features that characterize these processes.
  • list several agents with lipid-lowering, glucose regulating, or anti-thrombotic properties, and recognize how their physiologic actions are altered in the presence of diabetes.

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Course Outline

  • Introduction
      • Introduction
      • Physiological platelet activation
      • Physiological platelet activation
      • Figure 1. Platelet major signaling pathways
      • Physiological platelet activation
      • Physiological platelet activation
      • Physiological platelet activation
  • Contributing factors
      • Effect of insulin resistance on platelet function
      • Effect of hyperglycemia and AGEs
      • Effect of hyperglycemia and AGEs
      • Effect of hyperglycemia and AGEs
      • Effect of dyslipidemia
  • Platelet characteristics
      • Dysregulation of calcium signaling
      • Dysregulation of calcium signaling
      • Increased apoptosis
      • Increased apoptosis
      • Increased mean platelet volume
      • Hypo-responsiveness to anti-platelet therapy
      • Hypo-responsiveness to anti-platelet therapy
  • Conclusions
      • Conclusions
      • References

Additional Information

CE Credits: 1.00
ASCLS P.A.C.E.® Course #301-802-17
Florida Board of Clinical Laboratory Science, Course #20-591434
Instruction Level:  Intermediate
Category: Hematology
Exam:  Directly follows course material
15 questions out of a pool of 15
70% correct to receive credit(s)

MedTech ExPress Continuing Education, LLC is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program.
 

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Platelet aggregation. 
Image credit: Steffen Dietzel.


Figure 1. Platelet major signaling pathways.


MTE helix



 
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