Authentic and Spurious Causes of Thrombocytopenia (by LabCE)

1 P.A.C.E. contact hour(s)

(based on 328 customer ratings)

Author: Betty Ciesla MS, MT(ASCP)SH
Reviewers: Barbara Caldwell, MS, MT(ASCP)SH; Stephanie Clarke, MS, MT (ASCP)

Course provided by LabCE.

Platelets are the first responders to a bleeding incident. If the full platelet force does not arrive on the scene, bleeding will continue and petechiae, bruises, and perhaps even hemorrhaging will occur. A decreased platelet force (thrombocytopenia) may be caused by several diseases or disorders. On the other hand, a low platelet count may not actually mean that the full platelet force is not available to respond. It is up to the laboratory professional to determine if there is anything in the collection procedure that has artificially produced this low count. This course will increase your understanding of various authentic causes of thrombocytopenia and will alert you to various causes of spurious thrombocytopenia that you, as a medical laboratory scientist should be able to recognize and correct to prevent false reporting of thrombocytopenia.

See more courses in: Hematology

Included In These Course Packages

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Course number 578-046-22, approved through 5/31/2024
Course number 20-916913, approved through 5/31/2024


  • Define thrombocytopenia.
  • Recognize clinical signs that are associated with thrombocytopenia.
  • Identify conditions that cause the destruction of platelets.
  • Describe current treatments for various conditions that cause thrombocytopenia.
  • Identify conditions that cause decreased platelet production.
  • Recognize and correct falsely-decreased platelet counts.

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(based on 328 customer ratings)

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Course Outline

  • Introduction
      • Definition of Thrombocytopenia
      • Signs Associated With Thrombocytopenia
  • Conditions causing increased destruction and consumption of platelets
      • Increased Platelet Destruction
    • Idiopathic Thrombocytopenic Purpura
      • Immune Thrombocytopenic Purpura (ITP)
      • Acute Idiopathic Thrombocytopenia
      • Chronic Idiopathic Thrombocytopenic Purpura
      • Thrombocytopenia in Neonates
      • Treatment for ITP
    • Drug-Induced Thrombocytopenia
      • Drug-Induced Thrombocytopenia
      • Pathophysiology of Heparin-Induced Thrombocytopenia (HIT)
      • Additional Complications Related to Heparin-Induced Thrombocytopenia
    • Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome
      • Thrombotic Thrombocytopenic Purpura (TTP) and Hemolytic Uremic Syndrome (HUS)
      • Laboratory Findings
      • Treatment of TTP
    • Disseminated Intravascular Coagulation
      • Disseminated Intravascular Coagulation (DIC)
      • Clinical Signs and Symptoms
      • Laboratory Findings
      • Treatment of DIC
  • Conditions causing decreased platelet production
      • Diseases and Disorders That Affect the Bone Marrow and Decrease Platelet Production
  • Other causes of thrombocytopenia
      • Increased Splenic Sequestration and Thrombocytopenia
      • Dilutional Thrombocytopenia
  • Variables that cause a false thrombocytopenia
      • Preanalytic Variable Leading to False Thrombocytopenia
      • Pseudo-thrombocytopenia: Platelet Satellitism and Platelet Clumping
      • Importance of Addressing Platelet Variables
  • References
      • References

Additional Information

Level of instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, pathology residents, MLS students, and other health care personnel who have an interest in this subject matter.
Author information: Betty Ciesla, MS, MT(ASCP)SH is a faculty member at Morgan State University in Maryland. She holds an MS degree in Biomedical Communication. She has presented at national workshops in Hematology and Coagulation, authored several book chapters and articles on topics in Hematology, and served on the ASCP’s Tech Sample Committee, Education Program Committee, and most recently, the Hematology Examination Committee.
Reviewer Information:  
Barbara Caldwell, MS, MT(ASCP)SH is the administrative director of clinical laboratory services at Montgomery General Hospital in Olney, Maryland. She is also an experienced educator, having served as a Clinical Assistant Professor at the University of Maryland School of Medicine in the Department Of Medical and Research Technology. Ms. Caldwell holds an MS degree from the University of Maryland School of Medicine. She has authored numerous textbook chapters, articles, and abstracts related to topics in Hematology.
Stephanie Clarke, MS, MT(ASCP) has been teaching Medical Laboratory Science at the University of New Hampshire since fall 2014 and has served as the Assistant Program Director since fall 2015. She currently teaches Phlebotomy, Hematology, Hemostasis, Immunology/Serology, and Case Studies in Hematology. 

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Course provided by LabCE.

Normal platelet count on a peripheral blood smear.

Patient with petechiae and purpura (1).

platelet clumps copy

A diagram depicting a pulmonary embolism.


A transfusion.

The chemical formula for heparin.

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