Drug Metabolism (by LabCE)

2 P.A.C.E. contact hour(s)

(based on 667 customer ratings)

Author: Robert E. Moore, MLS(ASCP)CM, SCCM, TC(NRCC)
Reviewer: Kevin F. Foley PhD, MT, DABCC

Course provided by LabCE.

This is an advanced course, intended to present and discuss drug metabolism of the major drugs of abuse and its Importance in the interpretation of drug test results in the clinical laboratory. Topics include the effects of phase I and phase II metabolic reactions, the body's elimination of drugs and drug metabolites, and the various factors that affect drug metabolism.

See more courses in: Clinical Chemistry / Urinalysis / Toxicology

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-096-16, approved through 12/31/2018
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Clinical Chemistry/UA/Toxicology): 2 hour(s)
Course number 20-560495, approved through 9/18/2018

Objectives

  • Define drug metabolism.
  • Discuss the effects of phase I and phase II metabolic reactions on the drug molecule in the context of the enzymes that mediate them.
  • Describe the role that cytochrome P450 enzymes play in phase I metabolism.
  • Identify the CYP enzymes that are polymorphic and how these polymorphisms affect metabolism in some individuals.
  • Review enzyme inhibition and enzyme induction in the context of active or inactive parent or metabolite.
  • Summarize the metabolism of the major drugs of abuse.

Customer Ratings

(based on 667 customer ratings)

Course Outline

  • Metabolism
      • Drug Metabolism: Conversion of Parent Drug to Metabolites
  • Phase I Metabolic Reactions
      • Phase I Reactions: Hydrolysis, Reduction, and Oxidation
      • Cytochrome P450 (CYP Enzymes)
      • Cytochrome P450 (CYP Enzymes), continued
      • Polymorphisms
      • Polymorphisms, continued
      • Polymorphisms: Prodrugs
      • Enzyme Induction
      • Enzyme Induction, continued
      • Enzyme Inhibition
      • Enzyme Inhibition, continued
      • First Pass Hepatic Metabolism
  • Phase II Metabolic Reactions
      • Phase II Metabolic Reactions
      • Conjugation
  • Elimination of Drugs and Drug Metabolites
      • Elimination of Weak Acid and Weak Base Drugs
      • Elimination, continued
  • Factors Affecting Drug Metabolism
      • Factors Affecting Drug Metabolism
      • Genetics
      • Age Factors
      • Age Factors, continued
      • Diet
      • Hepatic Impairment
      • Renal Impairment
      • Weight and Gender
  • Drug Metabolism and its Importance in the Interpretation of Drug Tests in the Clinical Laboratory
      • Drug Metabolism and its Importance in the Interpretation of Drug Tests in the Clinical Toxicology Laboratory
      • Amphetamine
      • Methamphetamine
      • MDMA
      • Cocaine
      • Marijuana
      • Opiates: 6-MAM (AM)
      • Opiates: Codeine
      • Opiates: Morphine
      • Opiates: Hydrocodone
      • Opiates: Hydromorphone
      • Opiates: Oxycodone
      • Opiates: Oxymorphone
  • Conclusion
      • Conclusion
      • Conclusion, continued
  • References
      • References

Additional Information

Level of Instruction: Advanced
Intended Audience: Medical laboratory scientists, medical laboratory technicians, and MLS students. This course may also be of interest to pathology residents and other health care professionals who interested in drug metabolism.
Author information: Robert E. Moore, MLS(ASCP)CM, SCCM, TC(NRCC) is the lead technologist in the toxicology laboratory at Kaiser Permanente in Portland, Oregon where his responsibilities include methods development and validation, review of QC data, instrument troubleshooting, and employee training/competency assessment. In his career as a medical laboratory scientist, he has been a chemistry supervisor, toxicology supervisor, and laboratory director. He holds a Bachelors degree in Biology from Marshall University. 
Reviewer information: Kevin F. Foley, PhD, DABCC, MT, SC is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at East Carolina School of Medicine in North Carolina. He recieved a PhD in clinical pharmacology and toxicology from Brody School of Medicine, Greenville, NC. He has been working in laboratory medicine for over 15 years, starting his career as a medical technologist. 

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