2 P.A.C.E. contact hour(s)

(based on 708 customer ratings)

Course provided by LabCE.

See more courses in: Clinical Chemistry / Urinalysis / Toxicology

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-096-16, approved through 12/31/2018

Objectives

  • Define drug metabolism.
  • Discuss the effects of phase I and phase II metabolic reactions on the drug molecule in the context of the enzymes that mediate them.
  • Describe the role that cytochrome P450 enzymes play in phase I metabolism.
  • Identify the CYP enzymes that are polymorphic and how these polymorphisms affect metabolism in some individuals.
  • Review enzyme inhibition and enzyme induction in the context of active or inactive parent or metabolite.
  • Summarize the metabolism of the major drugs of abuse.

Customer Ratings

(based on 708 customer ratings)

Course Outline

  • Metabolism
      • Drug Metabolism: Conversion of Parent Drug to Metabolites
  • Phase I Metabolic Reactions
      • Phase I Reactions: Hydrolysis, Reduction, and Oxidation
      • Cytochrome P450 (CYP Enzymes)
      • Cytochrome P450 (CYP Enzymes), continued
      • Polymorphisms
      • Polymorphisms, continued
      • Polymorphisms: Prodrugs
      • Enzyme Induction
      • Enzyme Induction, continued
      • Enzyme Inhibition
      • Enzyme Inhibition, continued
      • First Pass Hepatic Metabolism
  • Phase II Metabolic Reactions
      • Phase II Metabolic Reactions
      • Conjugation
  • Elimination of Drugs and Drug Metabolites
      • Elimination of Weak Acid and Weak Base Drugs
      • Elimination, continued
  • Factors Affecting Drug Metabolism
      • Factors Affecting Drug Metabolism
      • Genetics
      • Age Factors
      • Age Factors, continued
      • Diet
      • Hepatic Impairment
      • Renal Impairment
      • Weight and Gender
  • Drug Metabolism and its Importance in the Interpretation of Drug Tests in the Clinical Laboratory
      • Drug Metabolism and its Importance in the Interpretation of Drug Tests in the Clinical Toxicology Laboratory
      • Amphetamine
      • Methamphetamine
      • MDMA
      • Cocaine
      • Marijuana
      • Opiates: 6-MAM (AM)
      • Opiates: Codeine
      • Opiates: Morphine
      • Opiates: Hydrocodone
      • Opiates: Hydromorphone
      • Opiates: Oxycodone
      • Opiates: Oxymorphone
  • Conclusion
      • Conclusion
      • Conclusion, continued
  • References
      • References
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