Hallmarks and Signaling of Cancer Cells (by LabCE)

1.5 P.A.C.E. contact hour(s)

(based on 202 customer ratings)

Author: Nancy Liu-Sullivan, PhD
Reviewers: Ralph Garippa, PhD and Kevin F. Foley, PhD, DABCC, MT, SC

Course provided by LabCE.

In the year 2000, Dr. Douglas Hanahan and Dr. Robert Weinberg depicted six hallmarks of cancer. Over the span of the next decade, drawing upon new discoveries and additional insight, they also delineated four additional cancer hallmarks. This course reviews how normal cells grow and cease to grow. It also describes the ten hallmarks of cancer with special attention to how cancer cells defy regulatory signals. Oncogenes are distinguished from tumor suppressor genes in this course.

See more courses in: Molecular Pathology

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1.5 hour(s)
Course number 578-048-21, approved through 8/31/2023
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Molecular Pathology): 1.5 hour(s)
Course number 20-877664, approved through 8/31/2023


  • Describe how normal cells grow and cease to grow.
  • Recognize the hallmarks of cancer with special attention to how cancer cells defy regulatory signals.
  • Distinguish oncogenes from tumor suppressor genes.
  • Explain the tumor microenvironment through glioblastoma (GBM).
  • List the opportunities and challenges in drug re-purposing and cancer drug discovery.

Customer Ratings

(based on 202 customer ratings)

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Course Outline

  • Topic 1: How do normal cells grow & halt growth?
      • The Cell Cycle
      • Cell Cycle Progression and Checkpoints
      • Additional Cell Cycle Checkpoints
      • The EGF/Ras Signaling: A Key Cell Growth Pathway
  • Topic 2: Cancer hallmarks (I)
      • Cancer Hallmarks: An Overview
      • Cancer Hallmark #1: Unstoppable Cell Growth
      • Cancer Hallmark #2: Defying Growth Suppression
      • Cancer Hallmark #3: Resisting Apoptosis
  • Topic 3: Cancer hallmarks (II)
      • Cancer Hallmark #4. Unlimited Replication Potential
      • Cancer Hallmark #5: Generating New Blood Vessels
      • Cancer Hallmark #6: Migration and Invasion
  • Topic 4: Cancer Hallmarks (III)
      • Cancer Hallmark #7: Metabolism Going Haywire
      • Cancer Hallmark #8: Escaping Immune Surveillance
      • Cancer Hallmark #9: Promoting Inflammation
      • Cancer Hallmark #10: Unstable Genome
  • Topic 5: A closer look at cancer through glioblastoma (GBM)
      • Tumorigenesis Stages
      • TGFβ signaling in glioblastoma
      • Tumor Microenvironment
  • Topic 6: Treatment strategies - An approach of drug re-purposing
      • Drug Repurposing - Old Drugs, New Tricks
      • Aspirin: An Encouraging Story
      • Drug Screening: 2D Versus 3D?
      • Combination Anti-cancer Therapy: Opportunities and Challenges
  • References
      • References

Additional Information

Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, pathology residents, MLS students, and other health care personnel who have an interest in this subject matter. 
Author information: Nancy Liu-Sullivan, PhD is the academic advisor of the Medical Technology program at the College of Staten Island (CSI), a senior college of the City University of New York. In addition to teaching and being the course leader, Dr. Liu-Sullivan also runs a research laboratory that focuses on identifying drug targets as novel chemotherapeutics for brain cancer using 3-D cell culture system. Before joining the biology faculty at the College of Staten Island, Dr. Liu-Sullivan worked as a senior research scientist at MSKCC, with more than a decade of cancer research expertise.
Reviewer information: Ralph Garippa, PhD, is Director of Gene Editing and RNAi Core Facility at Memorial Sloan Kettering Cancer Center, with more than two decades of drug discovery expertise and leadership. He is the former Head of Cell-Based High Throughput Screening and Microscopic Imaging-based High Content Screening at Hoffmann-La Roche’s Nutley NJ facility. His previous academic partners included Harvard University, Massachusetts General Hospital, and The Hebrew University in Jerusalem, Israel. Dr. Garippa holds a Ph.D. in Pharmacology from Columbia University and a B.A. degree in Biology from Fairleigh Dickinson University.
Reviewer information: Kevin F. Foley, PhD, DABCC, MT, is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at East Carolina School of Medicine in North Carolina. He received a PhD in clinical pharmacology and toxicology from Brody School of Medicine, Greenville, NC. He has been working in laboratory medicine for over 15 years, starting his career as a medical technologist.

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Course provided by LabCE.
FIGURE 4 keep

FIGURE 6 micro

FIGURE 7 2D vs 3D


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