(based on 144 customer ratings)

Course provided by LabCE.

See more courses in: Histology

Continuing Education Credits

Course number 20-547601, approved through 9/1/2020

Objectives

  • Recognize the value of predictive test results to clinical treatment decisions in human breast cancer.
  • Identify the main types of predictive testing performed in the histology laboratory.
  • Determine test methodologies used to identify the expression and amplification of human epidermal growth receptor 2 (HER2).
  • Examine current test methodologies used to identify the expression and amplification of HER2.
  • Identify compliance standards for validation, correlation, and proficiency testing under the guidelines set by the College of American Pathologists (CAP).

Customer Ratings

(based on 144 customer ratings)

Course Outline

  • Introduction
      • Predictive Testing is the Basis of Personalized Treatment
      • Predictive versus Prognostic
      • Response Rates to Common Therapies
      • Patient Benefit from Targeted Treatment Plans
  • Types of Breast Cancer
      • Incidence and Risk Factors
      • Breast Cancer Classification
      • Tumor Staging
      • Use of Immunohistochemistry (IHC) for Breast Tumor Classification
  • Theoretical Basis of Immunohistochemical Testing
      • Basics of Immunohistochemistry (IHC)
      • Variables Affecting Immunohistochemistry (IHC)
      • Types of Antibodies
      • Staining Patterns
  • Hormone Receptor Testing
      • Introduction to Estrogen Receptors and Progesterone Receptors
      • Hormonal Factors in Breast Cancer
      • Clinical Application of Estrogen Receptor (ER) and Progesterone Receptor (PR) Testing
      • Use of Immunohistochemistry (IHC) for Determining Estrogen Receptor (ER) and Progesterone Receptor (PR) Status
      • Scoring and Reporting of Estrogen Receptor (ER) and Progesterone Receptor (PR) Testing
      • Response Rates to Targeted Therapy
  • Human Epidermal Growth Factor Receptor 2 (HER2)
      • Introduction to Human Epidermal Growth Factor Receptor 2 (HER2)
      • Immunohistochemistry (IHC) Testing Options For HER2
      • Complimentary Testing Helps Assess HER2 Status
      • Targeted Treatment Based on HER2 Status
      • Impact of Variation in Test Results
      • 2013 IHC Scoring Criteria from the American Society of Clinical Oncologists (ASCO) and the College of American Pathologists (CAP)
  • HER2 Testing by In Situ Hybridization
      • Introduction
      • Specimen Handling and Fixation for Molecular and In Situ Methods
      • Introduction to HER2 Methods Using In Situ Hybridization (ISH)
      • Introduction to Fluorescent In Situ Hybridization (FISH) Methods
      • Fluorescence
      • Details of Fluorescent In Situ Hybridization (FISH)
      • Chromogenic In Situ Hybridization (CISH) Method for HER2
      • HER2 Test Method: Advantages and Disadvantages
      • CISH and FISH Scoring Criteria from the 2013 American Society of Clinical Oncologists (ASCO) and College of American Pathologists (CAP) Guideline Reco...
  • Regulation and Compliance with Predictive Markers
      • Validation, Quality Control, Regulations -- Why?
      • Regulation
      • Validation Purpose
      • Compliance Documentation
      • Mandatory Proficiency Testing
      • Comparison of 2007 to 2013 ASCO-CAP Guidelines for HER2 Testing
  • References
      • References
How to Subscribe
Single online course$25
Add to cart
  • Order for instant access through any computer, any browser.
  • No shipping, faxing, or waiting for certificates.
  • Print or save your certificate of completion as soon as you've completed the course.
  • You'll have 90 days to complete your purchased courses.
Course provided by LabCE.

 
ASCLS CE's design and platform are provided by MediaLab, Inc.