Myeloproliferative Neoplasms (by LabCE)

(based on 346 customer ratings)

Author: Leah Coppolino, MPH, CLS(NCA), MT(ASCP)
Reviewer: Rebecca J. Laudicina, PhD, MLS(ASCP)CM

Course provided by LabCE.

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Continuing Education Credits

Course number 20-547797, approved through 9/1/2020


  • Describe the 2008 World Health Organization classification system for myeloproliferative neoplasms (MPNs).
  • Compare and contrast the types of MPNs based upon etiology and patient symptoms.
  • Discuss the hematologic, cytogenetic, and other laboratory features associated with specific MPNs.
  • List common treatment options.

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(based on 346 customer ratings)

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Course Outline

  • Myeloproliferative Neoplasms
      • Introduction to Myeloproliferative Neoplasms (MPNs)
      • Classification of Myeloproliferative Neoplasms (MPNs)
      • Pathophysiology of Myeloproliferative Neoplasms (MPNs)
      • Symptoms
    • Chronic Myeloid Leukemia
      • Chronic Myeloid Leukemia (CML)
      • CML and the Philadelphia Chromosome
      • Laboratory Investigation of CML
      • CML Peripheral Blood Smear
      • Progression of CML
      • Treatment of CML
    • Chronic Neutrophilic Leukemia
      • Chronic Neutrophilic Leukemia (CNL)
      • Chronic Neutrophilic Leukemia (CNL), continued
    • Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia
      • Hypereosinophilic Syndrome (HES)
      • Chronic Eosinophilic Leukemia (CEL)
    • Essential Thrombocythemia
      • Essential Thrombocythemia (ET)
      • Diagnosis of Essential Thrombocythemia (ET)
      • Diagnosis of Essential Thrombocytosis (ET): Bone Marrow Findings
      • Essential Thrombocytosis (ET) Diagnosis
      • ET Treatment
    • Primary Myelofibrosis
      • Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis: World Health Organization (WHO) Criteria
    • Polycythemia Vera
      • Polycythemia Vera (PV)
      • Diagnosis of Polycythemia Vera (PV)
      • Treatment of Polycythemia Vera
    • Myeloproliferative Neoplasm, Unclassifiable (MPN-u)
      • Myeloproliferative Neoplasms, Unclassifiable (MPD-u)
  • Summary
      • Table: Laboratory Findings Associated with Myeloproliferative Neoplasms (MPNs)
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.
Author information: Leah Coppolino, MPH, CLS(NCA), MT(ASCP) is the Director of Education and Outreach in the Department of Pathology and Laboratory Medicine at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.
Reviewer information: Rebecca J. Laudicina, PhD, MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and PhD in Educational Psychology from Temple University. She is the author of numerous hematology-related publications.


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BM biopsy megakayocytes abnormal

Chronic Myelogenous Leukemia. Peripheral Blood Smear.
Image Credit: Paulo Henrique Orlandi Mourao

Bacterial infection, many neutrophils




therapeutic phlebotomy from ITXMdiagnostics website with permission 8-2014 LC

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