Immune Hemolytic Anemias (by LabCE)

2 P.A.C.E. contact hour(s)

(based on 659 customer ratings)

Author: Erin Tretter, MBA, MT(ASCP)
Reviewer: Kathy W. Jones, MS, MLS(ASCP)CM

Course provided by LabCE.

See more courses in: Blood Banking / Immunohematology

Included In These Course Packages

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-013-18, approved through 6/30/2020
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Blood Banking / Immunohematology): 2 hour(s)
Course number 20-659548, approved through 9/1/2020

Objectives

  • Compare the different types of immune hemolytic anemias.
  • Identify and investigate potential serologic discrepancies caused by autoimmune and drug-induced hemolytic anemias.
  • Differentiate the four mechanisms involved in drug-induced hemolytic anemias.
  • List medications that may be associated with drug-induced hemolytic anemia.

Customer Ratings

(based on 659 customer ratings)

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Course Outline

  • Immune Hemolytic Anemias
      • Introduction
      • Direct Antiglobulin Test (DAT)
      • Classification of Hemolytic Anemias
  • Alloimmune Hemolytic Anemia
      • Alloimmune Hemolytic Anemia
  • Autoimmune Hemolytic Anemias
      • Autoimmune Hemolytic Anemia (AIHA): Introduction
      • Symptoms of Autoimmune Hemolytic Anemias
      • Testing for Autoantibodies
      • Possible Serological and Laboratory Presentations
    • Cold Autoimmune Hemolytic Anemia
      • Cold Autoimmune Hemolytic Anemia
      • Cold Hemagglutinin Disease (CHD)
      • Paroxysmal Cold Hemoglobinuria (PCH)
      • PCH Donath-Landsteiner Test
      • ABO/Rh Typing in the Presence of Cold Autoantibodies
      • Laboratory Presentations of Cold Autoantibodies - Antibody ID and Detection
    • Warm Autoimmune Hemolytic Anemia
      • Warm Autoimmune Hemolytic Anemia (WAIHA)
      • Serological Characteristics in WAIHA
      • WAIHA Investigation: Serological Findings Following Elution
      • Possible Scenarios When Transfusions are Needed in the Presence of WAIHA
      • Detection and Identification of An Alloantibody in the Presence of a Warm-Reactive Autoantibody
      • Autologous Adsorption (Autoadsorption)
      • Allogeneic Adsorption
      • Transfusion Considerations for WAIHA
      • Treatment of WAIHA
    • Mixed-Type Autoimmune Hemolytic Anemia
      • Mixed Type Autoimmune Hemolytic Anemia (AIHA)
  • Drug-Induced Hemolytic Anemia
      • Drug-Induced Immune Hemolytic Anemia Introduction
      • Mechanisms
      • Drug Adsorption Mechanism
      • Immune Complex Mechanism
      • Membrane Modification (Non-Immune Adsorption of Proteins)
      • Induction of Autoimmunity
      • Treatment of Drug-Induced Immune Hemolytic Anemia
      • Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia
  • Case Study
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One Conclusion
  • Case Study
      • Case Study Two
      • Case Study Two, continued
      • Case Study Two, Conclusion
  • References
      • References

Additional Information

Author information: Erin Tretter, MBA, MT(ASCP), is currently the Rapid Response Laboratory Supervisor at Paoli Hospital. Erin received her Masters in Business Administration from Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor’s Society. She received her BS in Medical Technology from California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology and Chemistry. Erin is currently the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s Hospital for Children and has 7 years experience teaching immunohematology concepts and laboratory procedures to laboratory science students. She has also taught Blood Bank in the Clinical Laboratory Technician program at the Community College of Philadelphia.
Reviewer information: Kathy W. Jones, MS, MLS(ASCP)CM is currently an Associate Professor in the Medical Laboratory Science Program at Auburn University Montgomery where she is responsible for the program courses in Clinical Hematology and Clinical Immunology. She holds a BS degree in Biology as well as a Master’s degree in Adult Education from Troy University. She received her Medical Laboratory Science certificate from St. Margaret’s Hospital School of Medical Technology and will celebrate her 40th year in Laboratory Science this year. Before she became a full-time educator she served in various roles in the clinical laboratory which included five years as a Hematology Supervisor.
 

Keywords

These are the most common topics and keywords covered in Immune Hemolytic Anemias (by LabCE):

controls disease red blood cells anti-igg intravenous procedures rbcs paroxysmal intravascular vitro hemolysis titer infectious hemoglobin jaundice transfuse saunders non-specifically red blood cell immune non-reactive bilirubin serum autocontrol clinical plasma medicine saline warmer drug identification immune-mediated aiha drug-treated monospecific proceeding treatment anti-c3 autoadsorbed adsorption antigen non-immune transfusion discrepancies antihuman drug-adsorption anti-i fails immunoglobulins high-dose eluate blood banking polyspecific hemoglobinemia hemagglutinin button infection alloantibody transfusions antibody anemia autoadsorption laboratory cold-reactive specificity drug-induced erythematosus harmening newborn mononucleosis symptoms transfused amplitude diagnosis polychromatophilic philadelphia alloantibodies cells reactive erythrocyte warm-reactive reticulocyte autoantibodies autoantibody blood bank info pathologic demonstrable blood hematocrit hemoglobinuria considerations anti-p lupus adsorb rudmann davis specificities phenotype antigen-negative phenotypes crossmatches drug-antidrug body donath-landsteiner medication waiha autoadsorptions autoimmune hemolytic adsorptions agglutination indistinguishable serologic hemolysin reagents non-self penicillin antigens bethesda harvested adsorbed autologous antigen-antibody autoimmunity sensitizes antibodies elution modern globulin biphasic allogeneic serological anemias incubation donor contains antiglobulin
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