(based on 237 customer ratings)

Course provided by LabCE.

See more courses in: Clinical Chemistry / Urinalysis / Toxicology

Continuing Education Credits

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Clinical Chemistry/UA/Toxicology): 1.5 hour(s)
Course number 20-563183, approved through 9/1/2020

Objectives

  • Define therapeutic drug monitoring (TDM) and explain the rationale for this testing.
  • Explain the concept of elimination half-life.
  • List the criteria and attributes of commonly monitored drugs.
  • Discuss three methods that are used for the measurement of therapeutic drugs in serum.
  • Define pharmacogenomics, polymorphism and CYP450; explain what is meant by "individualized medicine" or "personalized medicine."
  • Explain the usefulness of CYP450 testing as well as its shortcomings.
  • List the four classifications of metabolizers and explain the clinical relevance of each.

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(based on 237 customer ratings)

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Course Outline

  • TDM
      • Introduction
      • Therapeutic Drug Monitoring Definition
      • Pharmacogenomics Definition
      • Basic Pharmacokinetics
      • Drug Concentration Over Time
      • Drug Metabolism
      • Drug Elimination
      • Half-Life
      • Bioavailability
      • Protein Binding
      • Protein Availability and Drug Dosing
      • Other Factors Affecting Drug Absorption and Distribution
      • Steady State
      • Steady State Example
      • Sampling
      • Peak and Trough Sampling Times
      • Why TDM?
      • Why TDM?
      • Unexpected Concentrations
      • TDM For All Drugs?
      • When is TDM Not Useful?
      • Alternative to TDM
      • Examples of Drugs That are Monitored by TDM
      • TDM for Antibiotics
      • TDM for Anticonvulsants
      • TDM for Immunosuppressants
      • TDM for Cardiac Medications
      • TDM for Theophylline
      • Laboratory Methods
      • PETINIA
      • FPIA
      • Chemiluminescence
  • Pharmacogenomics
      • Individualized Medicine
      • Polymorphism and CYP450
      • CYP450s
      • CYP2D6
      • Metabolizers
      • Enzyme Abnormalities and Drugs
      • Clinical Utility
      • Warfarin Metabolism
      • Warfarin Metabolism, continued
      • CYP450 Induction and Inhibition
      • CYP450 Induction and Inhibition, continued
      • Genotype versus Phenotype
      • Genotype versus Phenotype, continued
      • TDM and PGx
      • The Bottom Line
      • The Bottom Line, continued
  • References
      • References
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