Common Coagulopathies (by LabCE)

1 P.A.C.E. contact hour(s)

(based on 483 customer ratings)

Author: Kevin F. Foley PhD, MT, DABCC
Reviewer: Rory Huschka, M.Ed., MT(ASCP) & Laurie Bjerklie, M.Ed., MT(ASCP)

Course provided by LabCE.

This course addesses common coagulopathies and the laboratory testing used to diagnose and evaluate these disorders. Hemophilia A and B, Disseminated Intravascular Coagulation, VonWillebrand disease, and the Factor V Leiden mutation are explored. Lupus anticoagulants are discussed along with how they can be mitigated in laboratory analysis.

See more courses in: Hematology

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Course number 578-089-20, approved through 9/30/2022
Course number 20-789390, approved through 9/1/2022


  • Explain the cause of Hemophilia A and B and describe the testing used to evaluate these conditions.
  • Describe the symptoms of Disseminated Intravascular Coagulation (DIC) and the laboratory testing used to help diagnose it.
  • Describe the prevalence, pathology, and lab testing used to assess the Factor V Leiden mutation.
  • Describe the different forms of Von Willebrand disease and the platelet testing used to assess this condition.
  • Explain what a lupus anticoagulant is and how this interference can be identified and mitigated.

Customer Ratings

(based on 483 customer ratings)

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Course Outline

  • Coagulopathies
      • Introduction
  • Hemophilia
      • Hemophilia
      • Hemophilia A
      • Factor Activity Assays
      • Lab Interference
      • Hemophilia B
  • Disseminated Intravascular Coagulation
      • Fibrinolysis
      • Measuring Fibrinolysis
      • What is DIC?
      • Diagnosing Disseminated Intravascular Coagulation (DIC)
      • Lab Results in DIC
  • Hyper-coagulable Conditions
      • Thromboembolism
      • Protein C and S
      • Protein C and S Resistance
      • Testing for APC Resistance and Factor-V-Leiden
  • Von Willebrand's Disease
      • What is Von Willebrand's Disease?
      • Types of VWD
      • Testing for VWD
      • Testing for VWD (Continued)
      • Testing for VWD (Continued)
  • Lupus Anticoagulant
      • What is a Lupus Anticoagulant (LAC)?
      • APS versus LAC
      • Testing for LAC
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical technologists, medical technology students, and those interested in reviewing the fundamentals of coagulation.

Author Credentials:   Kevin F. Foley, PhD, DABCC, MT, SC is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at East Carolina School of Medicine in North Carolina. He recieved a PhD in clinical pharmacology and toxicology from Brody School of Medicine, Greenville, NC. He has been working in laboratory medicine for over 15 years, starting his career as a medical technologist.

Reviewer Credentials: Rory Huschka, M. Ed., MT(ASCP), has over 20 years of experience as a medical technologist, technical supervisor, professor, and manager. He is the former Director of Clinical Laboratory Science and Medical Laboratory Technician Programs at Brookline College. He is currently a Program Director at MediaLab, Inc. Rory holds a BS degree in Medical Technology from North Dakota State University and a Masters in Educational Leadership from Argosy University.
Laurie Bjerklie, M.Ed., MT(ASCP), is currently a professor at Rasmussen College in Fargo, ND for their MLT program where she teaches a variety of courses including hematology and microbiology. She is the former Program Director of the Clinical Laboratory Science program at DeVry University in Phoenix, Arizona. Bjerklie has over ten years of experience in higher education and continues to work part time as a bench tech. 

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Course provided by LabCE.


activity assay



Platelet Function Test

VWF binds platelets and collagen in the endothelium leading to clot formation.

ASCLS CE's design and platform are provided by MediaLab, Inc.