Precision Medicine-Molecular Mechanisms of Cancer Development and Actionable Genes (by LabCE)

2 P.A.C.E. contact hour(s)

(based on 18 customer ratings)

Author: Tabetha Sundin, PhD, HCLD (ABB), MB (ASCP)CM
Reviewer: Timothy Walls, M.D., M.S.

Course provided by LabCE.

This course covers some basic genetic principles as well as how changes to the genetic code can lead to carcinogenesis. The course also addresses how personalized medicine is aided by molecular diagnostics to match the patient with the correct targeted therapy.

See more courses in: Molecular Pathology

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-020-19, approved through 1/31/2021
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Molecular Pathology): 2 hour(s)
Course number 20-650801, approved through 9/1/2020

Objectives

  • Describe basic genetics principles including DNA replication and repair.
  • Discuss how changes to the genetic code can lead to tumor formation.
  • Discuss the role that genetics and the environment play in carcinogenesis.
  • Describe what personalized medicine is and the benefit that patients will receive if they are candidates for personalized medicine.
  • Describe technologies used by molecular diagnostics laboratories to genotype patient tumors in order to match them with the correct targeted therapy.

Customer Ratings

(based on 18 customer ratings)

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Course Outline

  • Genetics
      • Basic Mendelian Genetics
      • Basic Mendelian Genetics, Continued:
      • Darwinian Evolution
      • Central Dogma of Molecular Biology
      • Nucleic Acid
      • Protein
      • DNA Replication
      • Transcription
      • Translation
      • Stem Cells
      • Chromosomes
      • Karyotype
      • Cell cycle
  • DNA Damage and Repair
      • Mutation Types
      • Germline Mutations vs Somatic Mutations
      • DNA Damage
      • Genetic Contributions to Cancer
      • Physical Carcinogens
      • Chemical Carcinogens
      • Oncogenic Viruses
      • DNA Repair
      • Single-Strand Break Repair
      • Double-Strand Break Repair
  • Tumorigenesis
      • Tumorigenesis
      • Hallmarks of Cancer
      • Tumor Suppressors
      • Oncogenes
  • Personalized Medicine
      • Biomarkers
      • Molecular Methods for Biomarker Detection
      • PCR
      • Sanger Sequencing
      • Next-Generation Sequencing
      • Next Generation Sequencing Technologies
      • Chemotherapy
      • Companion Diagnostics
      • Immunotherapy
      • Personalized Medicine
  • References
      • References

Additional Information

Level of instruction: Intermediate 

Intended audience:  This course is intended for molecular biology bench technicians and technologists, supervisors, and administrators. 
Course description: This course covers some basic genetic principles as well as how changes to the genetic code can lead to carcinogenesis. The course also addresses how personalized medicine is aided by molecular diagnostics to match the patient with the correct targeted therapy.

Author information: Tabetha Sundin, PhD, HCLD (ABB), MB (ASCP)CM, has over 10 years of laboratory experience in cancer biology and clinical molecular diagnostics. She is the Scientific Director of Molecular Diagnostics and Serology at Sentara Healthcare. Dr. Sundin serves as a Speaker for AstraZeneca and Bristol-Myers Squibb covering multidisciplinary facilitation of biomarker testing in cancer patients. She is also an active member of the Association of Molecular Pathology (AMP) and involved with numerous efforts to support the molecular diagnostics field with American Medical Technologists (AMT) and Clinical & Laboratory Standards Institute (CLSI).

Reviewer information: Timothy Walls, M.D., M.S., is an AP/CP boarded pathologist. He has completed fellowships in medical microbiology as well as molecular genetic pathology. Currently he is the Director of Clinical Laboratories at Sentara Reference Laboratories. Timothy has earned his B.S. in Biochemistry, Cellular and Molecular Biology at the University of Tennessee, his M.S. in Forensic Science at Drexel University and his M.D. from the University of Tennessee Health Science Center.

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Course provided by LabCE.
Cancer stem cells model


DNA transcription


The first 4 cycles of PCR


Two hit malignant transformation with chromosome loss


Sanger Sequencing produces an <br />
electropherogram (right) that <br />
correlates with the DNA sequence


Inheritance of a germline mutation



 
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