Case Studies in Pediatric Hematology (by LabCE)

1 P.A.C.E. contact hour(s)

(based on 324 customer ratings)

Author: Kyle D. Mills, DO, MLS(ASCP)SH
Reviewer: Michelle Butina, PhD, MLS(ASCP)CM

Course provided by LabCE.

This course will expose the reader to six case studies in pediatric hematology. These cases involve hematopathology prevalent from birth to the beginning of adulthood (age 18). Each case begins with the history of present illness or HPI. After you have been given the opportunity to review pertinent laboratory studies, the concept will be reviewed, and the patient’s case will be explained with a focus on physiologic concepts in hematology.

See more courses in: Hematology

Included In These Course Packages

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Course number 578-071-21, approved through 11/30/2023
Course number 20-889700, approved through 11/30/2023


  • Calculate mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and corrected white blood cell (WBC) count.
  • Predict peripheral smear microscopic characteristics using basic hemogram parameters.
  • Correctly order the sequence of hematopoiesis, beginning with the hematopoietic stem cell.
  • Interpret common iron study results and state the blood lead level that currently represents toxicity.
  • Recall the diagnostic significance of erythrocyte/zinc protoporphyrin.
  • Identify laboratory testing panels that best assess for hematological conditions.
  • Categorize cytochemistry stains and immunophenotyping results in the setting of acute leukemias.
  • Identify characteristics of macrocytic anemias.
  • Define alpha and beta thalassemia and identify key characteristics of each.

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(based on 324 customer ratings)

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Course Outline

  • Approaching “Case Studies in Pediatric Hematology”
      • Approaching Case Studies in Pediatric Hematology
  • Case 1: Candace, a Four-Week-Old Infant Born Prematurely
      • History of Present Illness (HPI) for Candace
      • Relevant Laboratory Studies for Candace
      • Patient Diagnosis: Anemia of Prematurity
      • Review of Hematopoiesis
      • Review of Hematopoiesis (continued)
  • Case 2: Nicolás, an Eight-Month-Old Born in Mexico
      • History of Present Illness (HPI) for Nicolás
      • Relevant Laboratory Studies for Nicholás
      • Patient Diagnosis: Iron Deficiency Anemia
      • Comparing Iron Studies in Iron Deficiency Anemia versus Anemia of Chronic Disease
  • Case 3: Patrick, a Five-Year-Old with Stomach Pain
      • History of Present Illness (HPI) for Patrick
      • Relevant Laboratory Studies for Patrick
      • Patient Diagnosis: Lead Poisoning
      • Blood Lead Level Collection and Processing Issues
  • Case 4: Danielle, a 13-Year-Old Who Is Losing Weight
      • History of Present Illness (HPI) for Danielle
      • Relevant Laboratory Studies for Danielle
      • Patient Diagnosis: Megaloblastic Anemia
      • Folic Acid versus Vitamin B12 (Cobalamin) Deficiency
  • Case 5: Benton, a 2-Year-Old with "Flu" for a Month
      • History of Present Illness (HPI) for Benton
      • Relevant Laboratory Studies for Benton
      • Patient Diagnosis: Acute Lymphoblastic / Lymphocytic Leukemia (ALL)
      • Review of Immunophenotyping and Cytochemistry Staining in Leukemias
  • Case 6: Theo, a 12-Month-Old with Dark Urine
      • History of Present Illness (HPI) for Theo
      • Relevant Laboratory Studies for Theo
      • Hemoglobin Structure
      • Hemoglobin Structure (continued)
      • Patient Diagnosis: Beta Thalassemia Major
      • Key Points of Alpha Thalassemia
      • Key Points of Beta Thalassemia
  • References
      • References

Additional Information

Level of Instruction: Beginning

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students, pathology residents, and other healthcare personnel who are interested in the physiologic concepts surrounding pediatric hematology.

Author Information: Kyle D. Mills, DO, MLS(ASCP)SH, completed his professional medical education at the University of Pikeville - Kentucky College of Osteopathic Medicine in Pikeville, Kentucky, in 2018. He is currently pursuing residency in internal medicine at the University of Louisville in Louisville, Kentucky. Dr. Mills also holds a Bachelor of Health Science in Clinical Laboratory Sciences degree from the University of Kentucky and is an American Society for Clinical Pathology (ASCP) certified Medical Laboratory Scientist (MLS) and Specialist in Hematology (SH). Before attending medical school, Dr. Mills worked on the laboratory bench as a generalist and led a medical laboratory technician program.

Reviewer Information: Michelle Butina, PhD, MLS(ASCP)CM is currently the Program Director and Associate Professor for the Medical Laboratory Science Program, College of Health Sciences at the University of Kentucky in Lexington, Kentucky. Dr. Butina earned a PhD in Workforce Education from the University of Georgia in Athens, Georgia. She received a Masters of Science degree in Clinical Laboratory Science from Michigan State University in East Lancing, Michigan and a Bachelor of Science degree in Medical Technology from Winston-Salem State University in Winston-Salem North Carolina. 

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Course provided by LabCE.
all high wbc


Basophilic stippling

Heinz bodies_arrows

Hematopoiesis cell types scheme_Shutterstock

hypersegmented neutrophil_shutterstock_JB

microcytes hypochromic

Macrocytic Ovalocytes

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